EPID-19. CHANGES IN SURVIVAL OVER TIME FOR ALL PRIMARY BRAIN AND OTHER CNS TUMORS IN THE UNITED STATES

Abstract BACKGROUND Despite advances in cancer diagnosis and clinical care, survival for many primary brain other central nervous system (CNS) tumors remain poor. This study performs a comprehensive analysis on these tumors. METHODS Survival differences were determined utilizing the National Program of Cancer Registries Analytic file all CNS Overall 5 most common histopathologies within specific age groups (children ages 0-14 years, adolescents, young adults [AYA] 15-39 older 40+ years) determined. was compared three time periods: 2004-2007, 2008-2012, 2013-2017. Kaplan-Meier multivariable Cox proportional hazards models used to generate median survival, hazard ratios (HR) 95% confidence intervals (CI). Models adjusted sex, race/ethnicity, treatment pattern. Malignant non-malignant assessed separately. RESULTS Aside from hemangioma mesenchymal adults, no notable changes observed across periods For malignant tumors, significant improvements children with embryonal (logrank p = 0.00028) AYA anaplastic astrocytoma 0.0043). In improvement five except oligodendroglioma. Adjusted treatment, there 2008-2012 2013-2017, when (Children: HR 0.92, CI 0.87-0.98, 0.010 2008-2012; 0.91, 0.85-0.97, 0.005 2013-2017; AYA: 0.88-0.96, < 0.001, 0.87, 0.83-0.93, 0.001 2013-2017). CONCLUSIONS improved slightly 2013-2017 as 2004-2007. No